EC 4.2.3.135 - Δ6-protoilludene synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.135

Names

Accepted name:
Δ6-protoilludene synthase
Other name:
6-protoilludene synthase
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Δ6-protoilludene-forming)

Reaction

Comments:

Isolated from the fungus Armillaria gallica. Δ6-Protoilludene is the first step in the biosynthesis of the melleolides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Engels, B., Heinig, U., Grothe, T., Stadler, M., Jennewein, S.
    Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides.
    J. Biol. Chem. 286: 6871-6878 (2011). [PMID: 21148562]

[EC 4.2.3.135 created 2012]