EC 4.2.3.134 - 5-phosphonooxy-L-lysine phospho-lyase

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IntEnz Enzyme Nomenclature
EC 4.2.3.134

Names

Accepted name:
5-phosphonooxy-L-lysine phospho-lyase
Other names:
5-phosphohydroxy-L-lysine ammoniophospholyase
AGXT2L2 (gene name)
Systematic name:
(5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Tsai, C. H., Henderson, L. M.
    Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase.
    J. Biol. Chem. 249: 5784-5789 (1974). [PMID: 4412716]
  2. Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V., Van Schaftingen, E.
    Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.
    J. Biol. Chem. 287: 7246-7255 (2012). [PMID: 22241472]

[EC 4.2.3.134 created 2012]