EC - β-copaene synthase

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IntEnz Enzyme Nomenclature


Accepted name:
β-copaene synthase
Other name:
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, β-copaene-forming)




Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-δ-cadinene, β-cubebene, (+)-sativene and traces of several other sequiterpenoids [1-3]. β-Copaene is formed in the presence of Mg2+ but not Mn2+ [2]. See EC, (+)-δ-cadinene synthase, EC, β-cubebene synthase, and EC, (+)-sativene synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Agger, S., Lopez-Gallego, F., Schmidt-Dannert, C.
    Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus.
    Mol. Microbiol. 72: 1181-1195 (2009). [PMID: 19400802]
  2. Lopez-Gallego, F., Agger, S. A., Abate-Pella, D., Distefano, M. D., Schmidt-Dannert, C.
    Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.
    Chembiochem 11: 1093-1106 (2010). [PMID: 20419721]
  3. Lopez-Gallego, F., Wawrzyn, G. T., Schmidt-Dannert, C.
    Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis.
    Appl. Environ. Microbiol. 76: 7723-7733 (2010). [PMID: 20889795]

[EC created 2012]