EC 4.2.3.126 - γ-muurolene synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.126

Names

Accepted name:
γ-muurolene synthase
Other name:
Cop3
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lase (cyclizing, γ-muurolene-forming)

Reaction

Comments:

The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and α-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.125, α-muurolene synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Agger, S., Lopez-Gallego, F., Schmidt-Dannert, C.
    Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus.
    Mol. Microbiol. 72: 1181-1195 (2009). [PMID: 19400802]
  2. Lopez-Gallego, F., Wawrzyn, G. T., Schmidt-Dannert, C.
    Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis.
    Appl. Environ. Microbiol. 76: 7723-7733 (2010). [PMID: 20889795]

[EC 4.2.3.126 created 2012]