EC 4.2.3.115 - α-terpinene synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.115

Names

Accepted name:
α-terpinene synthase
Systematic name:
geranyl-diphosphate diphosphate-lyase (cyclizing, α-terpinene-forming)

Reaction

Comments:

The enzyme has been characterized from Dysphania ambrosioides (American wormseed). Requires Mg2+. Mn2+ is less effective. The enzyme will also use (3R)-linalyl diphosphate. The reaction involves a 1,2-hydride shift. The 1-pro-S hydrogen of geranyl diphosphate is lost.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Poulose, A. J., Croteau, R.
    gamma-Terpinene synthetase: a key enzyme in the biosynthesis of aromatic monoterpenes.
    Arch. Biochem. Biophys. 191: 400-411 (1978). [PMID: 736574]
  2. LaFever, R. E., Croteau, R.
    Hydride shifts in the biosynthesis of the p-menthane monoterpenes alpha-terpinene, gamma-terpinene, and beta-phellandrene.
    Arch. Biochem. Biophys. 301: 361-366 (1993). [PMID: 8460944]

[EC 4.2.3.115 created 2012]