EC - γ-terpinene synthase

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IntEnz Enzyme Nomenclature


Accepted name:
γ-terpinene synthase
Other names:
Systematic name:
geranyl-diphosphate diphosphate-lyase (cyclizing, γ-terpinene-forming)




Isolated from Thymus vulgaris (thyme) [1,2], Citrus limon (lemon) [3], Citrus unshiu (satsuma) [4] and Origanum vulgare (oregano) [5]. Requires Mg2+. Mn2+ less effective. The reaction involves a 1,2-hydride shift. The 5-pro-S hydrogen of geranyl diphosphate is lost. Traces of several other monoterpenoids are formed in addition to γ-terpinene.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102903


  1. Alonso, W. R., Croteau, R.
    Purification and characterization of the monoterpene cyclase gamma-terpinene synthase from Thymus vulgaris.
    Arch. Biochem. Biophys. 286 : 511-517 (1991). [PMID: 1897973]
  2. LaFever, R. E., Croteau, R.
    Hydride shifts in the biosynthesis of the p-menthane monoterpenes alpha-terpinene, gamma-terpinene, and beta-phellandrene.
    Arch. Biochem. Biophys. 301 : 361-366 (1993). [PMID: 8460944]
  3. Lucker, J., El Tamer, M. K., Schwab, W., Verstappen, F. W., van der Plas, L. H., Bouwmeester, H. J., Verhoeven, H. A.
    Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases.
    Eur. J. Biochem. 269 : 3160-3171 (2002). [PMID: 12084056]
  4. Suzuki, Y., Sakai, H., Shimada, T., Omura, M., Kumazawa, S., Nakayama, T.
    Characterization of gamma-terpinene synthase from Citrus unshiu (Satsuma mandarin).
    Biofactors 21 : 79-82 (2004). [PMID: 15630174]
  5. Crocoll, C., Asbach, J., Novak, J., Gershenzon, J., Degenhardt, J.
    Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis.
    Plant Mol. Biol. 73 : 587-603 (2010). [PMID: 20419468]

[EC created 2012]