EC 188.8.131.52 - 2-methylcitrate dehydratase
IntEnz Enzyme Nomenclature
17725 [IUBMB](2S,3S)-2-methylcitrate(2S,3S)-2-methylcitrateName origin: UniProt - CHECKED (C)Formula: C7H7O7
Charge: -3ChEBI compound status: CHECKED (C)=2-methyl-cis-aconitate2-methyl-cis-aconitateName origin: UniProt - CHECKED (C)Formula: C7H5O6
Charge: -3ChEBI compound status: CHECKED (C)
The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate . The enzyme can also use cis-aconitate as a substrate but more slowly . Both this enzyme and EC 184.108.40.206, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate .
Links to other databases
Purification and properties of 2-methylcitrate dehydratase from Yarrowia lipolytica.Agric. Biol. Chem. 45 : 2831-2837 (1981).
Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase.Eur. J. Biochem. 269 : 6184-6194 (2002). [PMID: 12473114]
[EC 220.127.116.11 created 1984, modified 2007]