EC - Lactoyl-CoA dehydratase

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IntEnz Enzyme Nomenclature


Accepted name:
lactoyl-CoA dehydratase
Other names:
acrylyl coenzyme A hydratase
lactoyl coenzyme A dehydratase
lactyl CoA dehydratase
lactyl-coenzyme A dehydrase
lactoyl-CoA hydro-lyase
Systematic name:
(R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)



A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018819
CAS Registry Number: 9031-12-3


  1. Baldwin, R.L., Wood, W.A. and Emery, R.S.
    Lactate metabolism by Peptostreptococcus elsdenii: evidence for lactyl coenzyme a dehydrase.
    Biochim. Biophys. Acta 97 : 202-213 (1965). [PMID: 14292829]
  2. Schweiger, G., Buckel, W.
    On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum.
    FEBS Lett. 171 : 79-84 (1984). [PMID: 6586495]
  3. Kuchta, R. D., Abeles, R. H.
    Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase.
    J. Biol. Chem. 260 : 13181-13189 (1985). [PMID: 4055736]
  4. Kuchta, R. D., Hanson, G. R., Holmquist, B., Abeles, R. H.
    Fe-S centers in lactyl-CoA dehydratase.
    Biochemistry 25 : 7301-7307 (1986). [PMID: 3026450]
  5. Hofmeister, A. E., Buckel, W.
    (R)-lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA.
    Eur. J. Biochem. 206 : 547-552 (1992). [PMID: 1597194]

[EC created 1972, modified 2012]