EC - Prephenate dehydratase

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IntEnz Enzyme Nomenclature


Accepted name:
prephenate dehydratase
Other name:
prephenate hydro-lyase (decarboxylating)
Systematic name:
prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)



This enzyme in the enteric bacteria also possesses chorismate mutase (EC activity, and converts chorismate into prephenate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00671
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004664
CAS Registry Number: 9044-88-6
UniProtKB/Swiss-Prot: (45) [show] [UniProt]


  1. Cerutti, P. and Guroff, G.
    Enzymatic formation of phenylpyruvic acid in Pseudomonas sp. (ATCC 11299A) and its regulation.
    J. Biol. Chem. 240 : 3034-3048 (1965). [PMID: 14342329]
  2. Cotton, R.G.H. and Gibson, F.
    The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase.
    Biochim. Biophys. Acta 100 : 76-88 (1965). [PMID: 14323651]
  3. Schmidt, J.C. and Zalkin, H.
    Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium.
    Biochemistry 8 : 174-181 (1969).

[EC created 1972]