EC 4.2.1.3 - Aconitate hydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.3

Names

Accepted name:
aconitate hydratase
Other names:
cis-aconitase
aconitase
citrate hydro-lyase
citrate(isocitrate) hydro-lyase
AcnB
2-methylaconitate hydratase
Systematic name:
citrate(isocitrate) hydro-lyase (cis-aconitate-forming)

Reactions

Cofactor

Comments:

Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00423
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003994 , GO:0047780
CAS Registry Number: 9024-25-3
UniProtKB/Swiss-Prot: (76) [show] [UniProt]

References

  1. Dickman, S.R.
    Aconitase.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K (Eds.) The Enzymes , 2nd ed. vol. 5 , Academic Press , New York , 1961 , 495-510
  2. Morrison, J.F.
    The purification of aconitase.
    Biochem. J. 56 : 99-105 (1954). [PMID: 13126098]
  3. Lauble, H., Kennedy, M.C., Beinert, H. and Stout, C.D.
    Crystal structures of aconitase with trans-aconitate and nitrocitrate bound.
    J. Mol. Biol. 237 : 437-451 (1994). [PMID: 8151704]

[EC 4.2.1.3 created 1961, modified 2003]