EC 4.2.1.3 - Aconitate hydratase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.2.1.3
Names
Accepted name:
aconitate hydratase
Other
names:
cis-aconitase
aconitase
citrate hydro-lyase
citrate(isocitrate) hydro-lyase
AcnB
2-methylaconitate hydratase
aconitase
citrate hydro-lyase
citrate(isocitrate) hydro-lyase
AcnB
2-methylaconitate hydratase
Systematic name:
citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
Reactions
- (1) citrate = isocitrate
- (1a) citrate = cis-aconitate + H2O
- (1b) cis-aconitate + H2O = isocitrate
Cofactor
Comments:
Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00423
Gene Ontology:
GO:0003994
,
GO:0047780
CAS Registry Number:
9024-25-3
References
-
Aconitase.In: Boyer, P.D., Lardy, H. and Myrbäck, K (Eds.) The Enzymes , 2nd ed. vol. 5 , Academic Press , New York , 1961 , 495-510
-
The purification of aconitase.Biochem. J. 56 : 99-105 (1954). [PMID: 13126098]
-
Crystal structures of aconitase with trans-aconitate and nitrocitrate bound.J. Mol. Biol. 237 : 437-451 (1994). [PMID: 8151704]
[EC 4.2.1.3 created 1961, modified 2003]