EC - Enoyl-CoA hydratase

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IntEnz Enzyme Nomenclature


Accepted name:
enoyl-CoA hydratase
Other names:
2-enoyl-CoA hydratase
2-octenoyl coenzyme A hydrase
β-hydroxyacid dehydrase
β-hydroxyacyl-CoA dehydrase
D-3-hydroxyacyl-CoA dehydratase
trans-2-enoyl-CoA hydratase
acyl coenzyme A hydrase
crotonyl hydrase
enol-CoA hydratase
enoyl coenzyme A hydrase (D)
enoyl coenzyme A hydrase (L)
enoyl coenzyme A hydratase
enoyl hydrase
hydratase, enoyl coenzyme A
short chain enoyl coenzyme A hydratase
short-chain enoyl-CoA hydratase
unsaturated acyl-CoA hydratase
Systematic name:
(3S)-3-hydroxyacyl-CoA hydro-lyase



Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC long-chain-enoyl-CoA hydratase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00150
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004300
CAS Registry Number: 9027-13-8
UniProtKB/Swiss-Prot: (260) [show] [UniProt]


  1. Moskowitz, G.J. and Merrick, J.M.
    Metabolism of poly-β-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-β-hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum.
    Biochemistry 8 : 2748-2755 (1969). [PMID: 5808333]
  2. Stern, J.R.
    Thioltranscrotylase and β-hydroxybutyryl CoA racemase activities of crystalline crotonase.
    Biochim. Biophys. Acta 26 : 641-643 (1957). [PMID: 13499425]

[EC created 1961]