EC 188.8.131.52 - Phosphinomethylmalate isomerase
IntEnz Enzyme Nomenclature
49504 [IUBMB]phosphinomethylmalatephosphinomethylmalateName origin: UniProt - CHECKED (C)Formula: C5H6O7P
Charge: -3ChEBI compound status: CHECKED (C)=
The enzyme, characterized from the bacterium Streptomyces viridochromogenes, is involved in bialaphos biosynthesis. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 184.108.40.206, glutamine synthetase. The similar enzyme EC 220.127.116.11, aconitate hydratase, cannot catalyse this reaction.
Links to other databases
The phosphinomethylmalate isomerase gene pmi, encoding an aconitase-like enzyme, is involved in the synthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes.Appl. Environ. Microbiol. 67 : 3603-3609 (2001). [PMID: 11472937]
[EC 18.104.22.168 created 2016]