EC 4.2.1.149 - Crotonobetainyl-CoA hydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.149

Names

Accepted name:
crotonobetainyl-CoA hydratase
Other names:
CaiD
L-carnityl-CoA dehydratase
Systematic name:
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming]

Reaction

Comments:

The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (25) [show] [UniProt]

References

  1. Engemann, C., Elssner, T., Kleber, H. P.
    Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
    Arch. Microbiol. 175 : 353-359 (2001). [PMID: 11409545]
  2. Elssner, T., Engemann, C., Baumgart, K., Kleber, H. P.
    Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli.
    Biochemistry 40 : 11140-11148 (2001). [PMID: 11551212]
  3. Engemann, C., Elssner, T., Pfeifer, S., Krumbholz, C., Maier, T., Kleber, H. P.
    Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
    Arch. Microbiol. 183 : 176-189 (2005). [PMID: 15731894]

[EC 4.2.1.149 created 2014]