EC 4.2.1.144 - 3-amino-5-hydroxybenzoate synthase

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IntEnz Enzyme Nomenclature
EC 4.2.1.144

Names

Accepted name:
3-amino-5-hydroxybenzoate synthase
Other names:
AHBA synthase
rifK (gene name)
Systematic name:
5-amino-5-deoxy-3-dehydroshikimate hydro-lyase (3-amino-5-hydroxybenzoate-forming)

Reaction

Cofactor

Comments:

A pyridoxal 5'-phosphate enzyme. The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-α-D-kanosamine [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kim, C. G., Yu, T. W., Fryhle, C. B., Handa, S., Floss, H. G.
    3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.
    J. Biol. Chem. 273 : 6030-6040 (1998). [PMID: 9497318]
  2. Eads, J. C., Beeby, M., Scapin, G., Yu, T. W., Floss, H. G.
    Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase.
    Biochemistry 38 : 9840-9849 (1999). [PMID: 10433690]
  3. Floss, H. G., Yu, T. W., Arakawa, K.
    The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.
    J. Antibiot. 64 : 35-44 (2011). [PMID: 21081954]

[EC 4.2.1.144 created 2013]