EC - 5'-oxoaverantin cyclase

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IntEnz Enzyme Nomenclature


Accepted name:
5'-oxoaverantin cyclase
Other name:
OAVN cyclase
Systematic name:
5'-oxoaverantin hydro-lyase [(1'S,5'S)-averufin forming]



Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC, versicolorin B synthase). Involved in aflatoxin biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Sakuno, E., Yabe, K., Nakajima, H.
    Involvement of two cytosolic enzymes and a novel intermediate, 5'-oxoaverantin, in the pathway from 5'-hydroxyaverantin to averufin in aflatoxin biosynthesis.
    Appl. Environ. Microbiol. 69 : 6418-6426 (2003). [PMID: 14602595]
  2. Sakuno, E., Wen, Y., Hatabayashi, H., Arai, H., Aoki, C., Yabe, K., Nakajima, H.
    Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
    Appl. Environ. Microbiol. 71 : 2999-3006 (2005). [PMID: 15932995]

[EC created 2013]