EC 4.2.1.140 - Gluconate/galactonate dehydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.140

Names

Accepted name:
gluconate/galactonate dehydratase
Other names:
gluconate dehydratase [ambiguous]
Sso3198 (gene name)
Pto0485 (gene name)
Systematic name:
D-gluconate/D-galactonate hydro-lyase

Reactions

Cofactor

Comments:

The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in Picrophilus torridus [3] and via the branched variant of the Entner-Doudoroff pathway in Sulfolobus solfataricus [1,2]. In vitro it utilizes D-gluconate with 6-10 fold higher catalytic efficiency than D-galactonate [1,3]. It requires Mg2+ for activity [1,2]. cf. EC 4.2.1.6, galactonate dehydratase, and EC 4.2.1.39, gluconate dehydratase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lamble, H. J., Milburn, C. C., Taylor, G. L., Hough, D. W., Danson, M. J.
    Gluconate dehydratase from the promiscuous Entner-Doudoroff pathway in Sulfolobus solfataricus.
    FEBS Lett. 576 : 133-136 (2004). [PMID: 15474024]
  2. Ahmed, H., Ettema, T. J., Tjaden, B., Geerling, A. C., van der Oost, J., Siebers, B.
    The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation.
    Biochem. J. 390 : 529-540 (2005). [PMID: 15869466]
  3. Reher, M., Fuhrer, T., Bott, M., Schonheit, P.
    The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
    J. Bacteriol. 192 : 964-974 (2010). [PMID: 20023024]

[EC 4.2.1.140 created 2013]