EC 4.2.1.132 - 2-hydroxyhexa-2,4-dienoate hydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.132

Names

Accepted name:
2-hydroxyhexa-2,4-dienoate hydratase
Other names:
tesE (gene name)
hsaE (gene name)
Systematic name:
4-hydroxy-2-oxohexanoate hydro-layse [(2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming]

Reaction

Comments:

This enzyme catalyses a late step in the bacterial steroid degradation pathway. The product, 4-hydroxy-2-oxohexanoate, forms a 2-hydroxy-4-hex-2-enolactone under acidic conditions.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034856
UniProtKB/Swiss-Prot:

References

  1. Horinouchi, M., Hayashi, T., Koshino, H., Kurita, T., Kudo, T.
    Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
    Appl. Environ. Microbiol. 71 : 5275-5281 (2005). [PMID: 16151114]

[EC 4.2.1.132 created 2012]