EC 18.104.22.168 - D-lactate dehydratase
IntEnz Enzyme Nomenclature
- (R)-lactate = methylglyoxal + H2O
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 22.214.171.124, lactoylglutathione lyase and EC 126.96.36.199, hydroxyacylglutathione hydrolase.
Links to other databases
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.J. Biol. Chem. 289 : 1662-1674 (2014). [PMID: 24302734]
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.BMC Evol. Biol. 14 : 86 (2014). [PMID: 24758716]
[EC 188.8.131.52 created 2011]