IntEnz

EC 4.2.1.130 - D-lactate dehydratase

IntEnz Enzyme Nomenclature
EC 4.2.1.130

Names

Reaction

• 27754 [IUBMB]
  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  methylglyoxal

  methylglyoxal

  Name origin: UniProt - CHECKED (C)

  CHEBI:17158

  Formula: C3H4O2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  (R)-lactate

  (R)-lactate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16004

  Formula: C3H5O3
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5, lactoylglutathione lyase and EC 3.1.2.6, hydroxyacylglutathione hydrolase.

Links to other databases

References

1. Hasim, S., Hussin, N. A., Alomar, F., Bidasee, K. R., Nickerson, K. W., Wilson, M. A.
   A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
   J. Biol. Chem. 289 : 1662-1674 (2014). [PMID: 24302734]
2. Zhao, Q., Su, Y., Wang, Z., Chen, C., Wu, T., Huang, Y.
   Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
   BMC Evol. Biol. 14 : 86 (2014). [PMID: 24758716]

[EC 4.2.1.130 created 2011]