EC 4.2.1.130 - D-lactate dehydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.130

Names

Accepted name:
D-lactate dehydratase
Other names:
glyoxylase III
GLO3
Systematic name:
(R)-lactate hydro-lyase

Reaction

Comments:

The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5, lactoylglutathione lyase and EC 3.1.2.6, hydroxyacylglutathione hydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019172
UniProtKB/Swiss-Prot: (14) [show] [UniProt]

References

  1. Hasim, S., Hussin, N. A., Alomar, F., Bidasee, K. R., Nickerson, K. W., Wilson, M. A.
    A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
    J. Biol. Chem. 289 : 1662-1674 (2014). [PMID: 24302734]
  2. Zhao, Q., Su, Y., Wang, Z., Chen, C., Wu, T., Huang, Y.
    Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
    BMC Evol. Biol. 14 : 86 (2014). [PMID: 24758716]

[EC 4.2.1.130 created 2011]