EC 4.2.1.130 - D-lactate dehydratase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.2.1.130
Names
Accepted name:
D-lactate dehydratase
Other
names:
glyoxylase III
GLO3
GLO3
Systematic name:
(R)-lactate hydro-lyase
Reaction
- (R)-lactate = methylglyoxal + H2O
Comments:
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5, lactoylglutathione lyase and EC 3.1.2.6, hydroxyacylglutathione hydrolase.
Links to other databases
Gene Ontology:
GO:0019172
References
-
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.J. Biol. Chem. 289 : 1662-1674 (2014). [PMID: 24302734]
-
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.BMC Evol. Biol. 14 : 86 (2014). [PMID: 24758716]
[EC 4.2.1.130 created 2011]