EC - Squalene—hopanol cyclase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
squalene—hopanol cyclase
Other name:
squalene—hopene cyclase [ambiguous]
Systematic name:
hopan-22-ol hydro-lyase



The enzyme produces the cyclization products hopene (cf. EC and hopanol from squalene at a constant ratio of 5:1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Hoshino, T., Nakano, S., Kondo, T., Sato, T., Miyoshi, A.
    Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring.
    Org. Biomol. Chem. 2 : 1456-1470 (2004). [PMID: 15136801]
  2. Sato, T., Kouda, M., Hoshino, T.
    Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius.
    Biosci. Biotechnol. Biochem. 68 : 728-738 (2004). [PMID: 15056909]

[EC created 2011]