EC 4.2.1.129 - Squalene—hopanol cyclase

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IntEnz Enzyme Nomenclature
EC 4.2.1.129

Names

Accepted name:
squalene—hopanol cyclase
Other name:
squalene—hopene cyclase [ambiguous]
Systematic name:
hopan-22-ol hydro-lyase

Reaction

Comments:

The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Hoshino, T., Nakano, S., Kondo, T., Sato, T., Miyoshi, A.
    Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring.
    Org. Biomol. Chem. 2 : 1456-1470 (2004). [PMID: 15136801]
  2. Sato, T., Kouda, M., Hoshino, T.
    Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius.
    Biosci. Biotechnol. Biochem. 68 : 728-738 (2004). [PMID: 15056909]

[EC 4.2.1.129 created 2011]