EC - Tetrahymanol synthase

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IntEnz Enzyme Nomenclature


Accepted name:
tetrahymanol synthase
Other name:
squalene—tetrahymanol cyclase
Systematic name:
squalene hydro-lyase (tetrahymanol forming)



The reaction occurs in the reverse direction.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Saar, J., Kader, J. C., Poralla, K., Ourisson, G.
    Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila.
    Biochim. Biophys. Acta 1075 : 93-101 (1991). [PMID: 1892870]
  2. Giner, J. L., Rocchetti, S., Neunlist, S., Rohmer, M., Arigoni, D.
    Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis.
    Chem. Commun. 3089-3091 (2005). [PMID: 15959594]

[EC created 2011]