EC 4.2.1.122 - Tryptophan synthase (indole-salvaging)

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 4.2.1.122

Names

Accepted name:
tryptophan synthase (indole-salvaging)
Other name:
tryptophan synthase β2
Systematic name:
L-serine hydro-lyase [adding indole, L-tryptophan-forming]

Reaction

Comments:

Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC 4.2.1.20) that forms L-tryptophan from L-serine and 1-C-(indol-3-yl)glycerol 3-phosphate via an indole intermediate. This intermediate, which is formed by the α subunits, is transferred in an internal tunnel to the β units, which convert it to tryptophan. In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. This enzyme, which does not combine with the α unit to form a complex, salvages the lost indole back to L-tryptophan. It has a much lower Km for indole than the β subunit of EC 4.2.1.20.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052684

References

  1. Hettwer, S., Sterner, R.
    A novel tryptophan synthase β-subunit from the hyperthermophile Thermotoga maritima. Quaternary structure, steady-state kinetics, and putative physiological role.
    J. Biol. Chem. 277: 8194-8201 (2002). [PMID: 11756459]

[EC 4.2.1.122 created 2011]