EC 4.2.1.122 - Tryptophan synthase (indole-salvaging)
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IntEnz Enzyme Nomenclature
EC 4.2.1.122
Names
Accepted name:
tryptophan synthase (indole-salvaging)
Other
name:
tryptophan synthase β2
Systematic name:
L-serine hydro-lyase [adding indole, L-tryptophan-forming]
Reaction
- L-serine + indole = L-tryptophan + H2O
Comments:
Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC 4.2.1.20) that forms L-tryptophan from L-serine and 1-C-(indol-3-yl)glycerol 3-phosphate via an indole intermediate. This intermediate, which is formed by the α subunits, is transferred in an internal tunnel to the β units, which convert it to tryptophan. In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. This enzyme, which does not combine with the α unit to form a complex, salvages the lost indole back to L-tryptophan. It has a much lower Km for indole than the β subunit of EC 4.2.1.20.
Links to other databases
Gene Ontology:
GO:0052684
References
-
A novel tryptophan synthase β-subunit from the hyperthermophile Thermotoga maritima. Quaternary structure, steady-state kinetics, and putative physiological role.J. Biol. Chem. 277 : 8194-8201 (2002). [PMID: 11756459]
[EC 4.2.1.122 created 2011]