EC 220.127.116.11 - 3-hydroxypropionyl-CoA dehydratase
IntEnz Enzyme Nomenclature
- 3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea . The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA .
Links to other databases
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.Science 318 : 1782-1786 (2007). [PMID: 18079405]
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.J. Bacteriol. 191 : 4572-4581 (2009). [PMID: 19429610]
[EC 18.104.22.168 created 2009]