EC 4.2.1.112 - Acetylene hydratase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 4.2.1.112

Names

Accepted name:
acetylene hydratase
Other names:
AH
AHy
acetaldehyde hydro-lyase
Systematic name:
acetaldehyde hydro-lyase (acetylene-forming)

Reaction

Cofactors

Comments:

This is a non-redox-active enzyme that contains two molybdopterin guanine dinucleotide (MGD) cofactors, a tungsten centre and a cubane type [4Fe-4S] cluster [2]. The tungsten centre binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct hydrophobic pocket [2]. Ethylene cannot act as a substrate [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018818
UniProtKB/Swiss-Prot:

References

  1. Rosner, B.M. and Schink, B.
    Purification and characterization of acetylene hydratase of Pelobacter acetylenicus, a tungsten iron-sulfur protein.
    J. Bacteriol. 177: 5767-5772 (1995). [PMID: 7592321]
  2. Seiffert, G.B., Ullmann, G.M., Messerschmidt, A., Schink, B., Kroneck, P.M.H. and Einsle, O.
    Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase.
    Proc. Natl. Acad. Sci. USA 104: 3073-3077 (2007). [PMID: 17360611]

[EC 4.2.1.112 created 2007]