EC 22.214.171.124 - 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase
IntEnz Enzyme Nomenclature
18933 [IUBMB](24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oyl-CoA(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoAName origin: UniProt - CHECKED (C)Formula: C48H76N7O21P3S
Charge: -4ChEBI compound status: CHECKED (C)=(24E)-3α,7α,12α-trihydroxy-5β-cholest-24-en-26-oyl-CoA(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoAName origin: UniProt - CHECKED (C)Formula: C48H74N7O20P3S
Charge: -4ChEBI compound status: CHECKED (C)
This enzyme forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. The enzyme is involved in the β-oxidation of the cholesterol side chain in the cholic-acid-biosynthesis pathway.
Links to other databases
Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis.Biochem. J. 328: 377-382 (1998). [PMID: 9371691]
The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids.Biochem. Biophys. Res. Commun. 221: 271-278 (1996). [PMID: 8619845]
Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid.Chem. Pharm. Bull. 36: 134-141 (1988).
Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid.Chem. Pharm. Bull. 36: 142-145 (1988).
Conjugation reactions catalyzed by bifunctional proteins related to β-oxidation in bile acid biosynthesis.Steroids 66: 107-114 (2001). [PMID: 11146090]
The enzymes, regulation, and genetics of bile acid synthesis.Annu. Rev. Biochem. 72: 137-174 (2003). [PMID: 12543708]
[EC 126.96.36.199 created 2005]