EC 4.2.1.1 - Carbonic anhydrase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.2.1.1
Names
Accepted name:
carbonic anhydrase
Other
names:
anhydrase
carbonate anhydrase
carbonic acid anhydrase
carbonate dehydratase
carbonic anhydrase A
carboxyanhydrase
carbonic dehydratase
carbonate hydro-lyase
carbonate anhydrase
carbonic acid anhydrase
carbonate dehydratase
carbonic anhydrase A
carboxyanhydrase
carbonic dehydratase
carbonate hydro-lyase
Systematic name:
carbonic acid hydro-lyase (carbon-dioxide-forming)
Reaction
-
10748 [IUBMB]H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)hydrogencarbonateName origin: UniProt - CHECKED (C)Formula: CHO3
Charge: -1ChEBI compound status: CHECKED (C)=CO2Name origin: UniProt - CHECKED (C)Formula: CO2
Charge: 0ChEBI compound status: CHECKED (C)
Cofactor
Comments:
The enzyme catalyses the reversible hydration of gaseous CO2 to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. Three distinct classes exist, and appear to have evolved independently. Contains zinc.
Links to other databases
Protein domains and families:
PROSITE:PDOC00146
,
PROSITE:PDOC00586
Gene Ontology:
GO:0004089
CAS Registry Number:
9001-03-0
References
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Carbonic anhydrase.Nature 144 : 442-443 (1939).
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Structure, refinement, and function of carbonic anhydrase isozymes: refinement of human carbonic anhydrase I.Ann. N. Y. Acad. Sci. 429 : 49-60 (1984). [PMID: 6430186]
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Purification and characterization of human salivary carbonic anhydrase.J. Biol. Chem. 262 : 1382-1388 (1987). [PMID: 2433278]
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A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila.Biochemistry 39 : 9222-9231 (2000). [PMID: 10924115]
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Prokaryotic carbonic anhydrases.FEMS Microbiol. Rev. 24 : 335-366 (2000). [PMID: 10978542]
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Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity.Protein Sci. 10 : 911-922 (2001). [PMID: 11316870]
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Why is carbonic anhydrase essential to Escherichia coli?J. Bacteriol. 185 : 6415-6424 (2003). [PMID: 14563877]
[EC 4.2.1.1 created 1961, modified 2016]