EC 4.1.99.5 - Aldehyde oxygenase (deformylating)

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IntEnz Enzyme Nomenclature
EC 4.1.99.5

Names

Accepted name:
aldehyde oxygenase (deformylating)
Other names:
aldehyde decarbonylase
decarbonylase
octadecanal decarbonylase
octadecanal alkane-lyase
Systematic name:
a long-chain aldehyde alkane-lyase

Reactions

Cofactor

Comments:

Contains a diiron center. Involved in the biosynthesis of alkanes. The enzyme from the cyanobacterium Nostoc punctiforme PCC 73102 is only active in vitro in the presence of ferredoxin, ferredoxin reductase and NADPH, and produces mostly C15 to C17 alkanes [2]. The enzyme from pea (Pisum sativum) produces alkanes of chain length C18 to C32 and is inhibited by metal-chelating agents [1]. The substrate for this enzyme is formed by EC 1.2.1.80, acyl-[acyl-carrier protein] reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:1990465 , GO:0009924
CAS Registry Number: 94185-90-7
UniProtKB/Swiss-Prot: (25) [show] [UniProt]

References

  1. Cheesbrough, T.M. and, Kolattukudy, P.E.
    Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a particulate preparation from Pisum sativum.
    Proc. Natl. Acad. Sci. USA 81: 6613-6617 (1984). [PMID: 6593720]
  2. Schirmer, A., Rude, M. A., Li, X., Popova, E., del Cardayre, S. B.
    Microbial biosynthesis of alkanes.
    Science 329: 559-562 (2010). [PMID: 20671186]
  3. Warui, D. M., Li, N., Nørgaard, H., Krebs, C., Bollinger, J. M., Booker, S. J.
    Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase.
    J. Am. Chem. Soc. 133: 3316-3319 (2011). [PMID: 21341652]
  4. Li, N., Chang, W. C., Warui, D. M., Booker, S. J., Krebs, C., Bollinger, J. M.
    Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases.
    Biochemistry 51: 7908-7916 (2012). [PMID: 22947199]

[EC 4.1.99.5 created 1989, modified 2011, modified 2013]