EC - Deoxyribodipyrimidine photo-lyase

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IntEnz Enzyme Nomenclature


Accepted name:
deoxyribodipyrimidine photo-lyase
Other names:
DNA cyclobutane dipyrimidine photolyase
DNA photolyase
DNA-photoreactivating enzyme
PhrB photolyase
deoxyribodipyrimidine photolyase
deoxyribonucleate pyrimidine dimer lyase (photosensitive)
deoxyribonucleic cyclobutane dipyrimidine photolyase
deoxyribonucleic photolyase
dipyrimidine photolyase (photosensitive)
photoreactivating enzyme
phr A photolyase
Systematic name:
deoxyribocyclobutadipyrimidine pyrimidine-lyase




A flavoprotein (FAD), containing a second chromophore group. The enzyme catalyses the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00331 , PROSITE:PDOC00832
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003904
CAS Registry Number: 37290-70-3
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Eker, A.P.M. and Fichtinger-Schepman, A.M.J.
    Studies on a DNA photoreactivating enzyme from Streptomyces griseus. II. Purification of the enzyme.
    Biochim. Biophys. Acta 378: 54-63 (1975). [PMID: 804322]
  2. Sancar, G.B., Smith, F.W., Reid, R., Payne, G., Levy, M. and Sancar, A.
    Action mechanism of Escherichia coli DNA photolyase. I. Formation of the enzyme-substrate complex.
    J. Biol. Chem. 262: 478-485 (1987). [PMID: 3539939]
  3. Setlow, J.K. and Bollum, F.J.
    The minimum size of the substrate for yeast photoreactivating enzyme.
    Biochim. Biophys. Acta 157: 233-237 (1968). [PMID: 5649902]

[EC created 1972]