EC 4.1.99.20 - 3-amino-4-hydroxybenzoate synthase

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IntEnz Enzyme Nomenclature
EC 4.1.99.20

Names

Accepted name:
3-amino-4-hydroxybenzoate synthase
Other names:
3,4-AHBA synthase
griH (gene name)
Systematic name:
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate hydro-lyase (cyclizing, 3-amino-4-hydroxybenzoate-forming)

Reaction

Cofactor

Comments:

Requires Mn2+ for maximum activity. The reaction is suggested to take place in several steps. Schiff base formation, double bond migration and dephosphorylation followed by ring opening and closing to form a pyrrolidine ring, and finally dehydration to form the product 3-amino-4-hydroxybenzoate. In the bacterium Streptomyces griseus the enzyme is involved in biosynthesis of grixazone, a yellow pigment that contains a phenoxazinone chromophore.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Suzuki, H., Ohnishi, Y., Furusho, Y., Sakuda, S., Horinouchi, S.
    Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes.
    J. Biol. Chem. 281 : 36944-36951 (2006). [PMID: 17003031]

[EC 4.1.99.20 created 2013, modified 2016]