EC - Benzylsuccinate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
benzylsuccinate synthase
Other name:
benzylsuccinate fumarate-lyase
Systematic name:
benzylsuccinate fumarate-lyase (toluene-forming)



A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018805


  1. Beller, H.R. and Spormann, A.M.
    Analysis of the novel benzylsuccinate synthase reaction for anaerobic toluene activation based on structural studies of the product.
    J. Bacteriol. 180 : 5454-5457 (1998). [PMID: 9765580]
  2. Leuthner, B., Leutwein, C., Schultz, H., Hörth, P., Haehnel, W., Schiltz, E., Schägger, H. and Heider, J.
    Biochemical and genetic characterisation of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism.
    Mol. Microbiol. 28 : 615-628 (1998). [PMID: 9632263]

[EC created 2000]