EC 4.1.3.41 - 3-hydroxy-D-aspartate aldolase

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IntEnz Enzyme Nomenclature
EC 4.1.3.41

Names

Accepted name:
3-hydroxy-D-aspartate aldolase
Other name:
D-3-hydroxyaspartate aldolase
Systematic name:
3-hydroxy-D-aspartate glyoxylate-lyase (glycine-forming)

Reactions

Cofactor

Comments:

A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificansy IFO 13301, is strictly D-specific as to the α-position of the substrate, but accepts both the threo and erythro forms at the β-position. The erythro form is a far better substrate (about 100 fold). The enzyme can also accept D-allothreonine, D-threonine, erythro-3-phenyl-D-serine and threo-3-phenyl-D-serine. Different from EC 4.1.3.14, erythro-3-hydroxy-L-aspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Liu, J. Q., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S.
    A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning.
    Appl. Microbiol. Biotechnol. 62: 53-60 (2003). [PMID: 12835921]

[EC 4.1.3.41 created 2010]