EC 4.1.3.40 - Chorismate lyase

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IntEnz Enzyme Nomenclature
EC 4.1.3.40

Names

Accepted name:
chorismate lyase
Other names:
CL
CPL
UbiC
Systematic name:
chorismate pyruvate-lyase (4-hydroxybenzoate-forming)

Reaction

Comments:

This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008813
UniProtKB/Swiss-Prot: (148) [show] [UniProt]

References

  1. Nichols, B.P. and Green, J.M.
    Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase.
    J. Bacteriol. 174: 5309-5316 (1992). [PMID: 1644758]
  2. Siebert, M., Severin, K. and Heide, L.
    Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase.
    Microbiology 140: 897-904 (1994). [PMID: 8012607]
  3. Meganathan, R.
    Ubiquinone biosynthesis in microorganisms.
    FEMS Microbiol. Lett. 203: 131-139 (2001). [PMID: 11583838]

[EC 4.1.3.40 created 2007]