EC - Hydroxymethylglutaryl-CoA lyase

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IntEnz Enzyme Nomenclature


Accepted name:
hydroxymethylglutaryl-CoA lyase
Other names:
3-hydroxy-3-methylglutaryl CoA cleaving enzyme
3-hydroxy-3-methylglutaryl coenzyme A lyase
3-hydroxy-3-methylglutaryl-CoA lyase
hydroxymethylglutaryl coenzyme A lyase
hydroxymethylglutaryl coenzyme A-cleaving enzyme
HMG-CoA lyase
3-hydroxy-3-methylglutarate-CoA lyase
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
Systematic name:
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00813
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004419
CAS Registry Number: 9030-83-5
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Bachhawat, B.K., Robinson, W.G. and Coon, M.J.
    The enzymatic cleavage of β-hydroxy-β-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A.
    J. Biol. Chem. 216: 727-736 (1955). [PMID: 13271348]

[EC created 1961]