EC 4.1.3.36 - 1,4-dihydroxy-2-naphthoyl-CoA synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 4.1.3.36
Names
Accepted name:
1,4-dihydroxy-2-naphthoyl-CoA synthase
Other
names:
1,4-dihydroxy-2-naphthoate synthase
dihydroxynaphthoate synthase
dihydroxynaphthoic acid synthetase
DHNA synthetase
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing)
naphthoate synthase
MenB
o-succinylbenzoyl-CoA dihydratase (cyclizing)
dihydroxynaphthoate synthase
dihydroxynaphthoic acid synthetase
DHNA synthetase
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing)
naphthoate synthase
MenB
o-succinylbenzoyl-CoA dihydratase (cyclizing)
Systematic name:
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dihydratase (cyclizing)
Reaction
- 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
Comments:
This enzyme is involved in the synthesis of 1,4-dihydroxy-2-naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone (vitamin K1 in plants), and many plant pigments. The coenzyme A group is subsequently removed from the product by EC 3.1.2.28, 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00150
Gene Ontology:
GO:0008935
CAS Registry Number:
61328-42-5
References
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Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes.J. Bacteriol. 140 : 92-98 (1979). [PMID: 500558]
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4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis.Z. Naturforsch. C: Biosci. 42 : 1207-1214 (1987). [PMID: 2966501]
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Recruitment of a foreign quinone into the A1 site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. PCC 6803.J. Biol. Chem. 275 : 8523-8530 (2000). [PMID: 10722690]
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Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.J. Biol. Chem. 278 : 42352-42360 (2003). [PMID: 12909628]
[EC 4.1.3.36 created 1992, modified 2010]