EC - 4-hydroxy-4-methyl-2-oxoglutarate aldolase

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxy-4-methyl-2-oxoglutarate aldolase
Other names:
4-hydroxy-4-methyl-2-ketoglutarate aldolase
γ-methyl-γ-hydroxy-α-ketoglutaric aldolase
pyruvate aldolase
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase
HMG aldolase
CHA aldolase
4-carboxy-4-hydroxy-2-oxoadipate aldolase
Systematic name:
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)




Requires a divalent metal ion [3]. This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), phthalate, syringate and gallate [1-3]. The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2-oxoglutarate to glyoxylate and pyruvate, and also catalyses the reaction of EC (oxaloacetate decarboxylase) [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047443
CAS Registry Number: 37290-65-6
UniProtKB/Swiss-Prot: (99) [show] [UniProt]


  1. Tack, B. F., Chapman, P. J., Dagley, S.
    Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase.
    J. Biol. Chem. 247: 6444-6449 (1972). [PMID: 5076765]
  2. Wood, W.A.
    2-Keto-3-deoxy-6-phosphogluconic and related aldolases.
    In: Boyer, P.D. (Ed.) The Enzymes, 3rd ed. vol. 7, Academic Press, New York, 1972, 281-302
  3. Maruyama, K.
    Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
    J. Biochem. 93: 557-565 (1983). [PMID: 6841353]
  4. Nogales, J., Canales, A., Jimenez-Barbero, J., Serra, B., Pingarron, J. M., Garcia, J. L., Diaz, E.
    Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
    Mol. Microbiol. 79: 359-374 (2011). [PMID: 21219457]

[EC created 1972, modified 2012]