EC 4.1.3.1 - Isocitrate lyase

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IntEnz Enzyme Nomenclature
EC 4.1.3.1

Names

Accepted name:
isocitrate lyase
Other names:
threo-DS-isocitrate glyoxylate-lyase
isocitrase
isocitratase
isocitritase
ICL
isocitrate glyoxylate-lyase
Systematic name:
isocitrate glyoxylate-lyase (succinate-forming)

Reaction

Comments:

The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00145
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004451
CAS Registry Number: 9045-78-7
UniProtKB/Swiss-Prot: (56) [show] [UniProt]

References

  1. McFadden, B.A. and Howes, W.V.
    Crystallisation and some properties of isocitrate lyase from Pseudomonas indigofera.
    J. Biol. Chem. 238: 1737-1742 (1963).
  2. Shiio, I, Shiio, T. and McFadden, B.A.
    Isocitrate lyase from Pseudomonas indigofera. I. Preparation, amino acid composition and molecular weight.
    Biochim. Biophys. Acta 96: 114-122 (1965). [PMID: 14285253]
  3. Vickery, H.B.
    A suggested new nomenclature for the isomers of isocitric acid.
    J. Biol. Chem. 237: 1739-1741 (1962). [PMID: 13925783]

[EC 4.1.3.1 created 1961]