EC 4.1.2.n2 - 2-hydroxyphytanoyl-CoA lyase

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IntEnz Enzyme Nomenclature
EC 4.1.2.n2

This is a preliminary EC number. The content has not yet been validated and included in the official IUBMB Enzyme list.

Names

Accepted name:
2-hydroxyphytanoyl-CoA lyase
Other name:
2-HPCL
Systematic name:
2-hydroxyphytanoyl-CoA pristanal-lyase (formyl-CoA-forming)

Reactions

Cofactors

Comments:

Requires Mg2+ and thiamine diphosphate (TPP). The enzyme can also use other 3-methyl-branched fatty acids as substrates.

Links to other databases

Enzymes and pathways: ENZYME@ExPASy

References

  1. Foulon, V., Antonenkov, V. D., Croes, K., Waelkens, E., Mannaerts, G. P., Van Veldhoven, P. P., Casteels, M.
    Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during α-oxidation of 3-methyl-branched fatty acids.
    Proc. Natl. Acad. Sci. USA 96: 10039-10044 (1999). [PMID: 10468558]

[EC 4.1.2.n2 created 2010]