EC - Indole-3-glycerol-phosphate lyase

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IntEnz Enzyme Nomenclature


Accepted name:
indole-3-glycerol-phosphate lyase
Other names:
tryptophan synthase α
indoleglycerolphosphate aldolase
indole glycerol phosphate hydrolase
indole synthase
indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase
indole-3-glycerol phosphate lyase
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase
Systematic name:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming)



Forms part of the defence mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyses one of the steps in the formation of the cyclic hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) [1]. This enzyme resembles the α-subunit of EC, tryptophan synthase [3] but, unlike tryptophan synthase, its activity is independent of the β-subunit and free indole is released [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00151
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033984


  1. Yanofsky, C.
    The enzymatic conversion of anthranilic acid to indole.
    J. Biol. Chem. 223 : 171-184 (1956). [PMID: 13376586]
  2. Frey, M., Chomet, P., Glawischnig, E., Stettner, C., Grün, S., Winklmair, A., Eisenreich, W., Bacher, A., Meeley, R.B., Briggs, S.P., Simcox, K. and Gierl, A.
    Analysis of a chemical plant defense mechanism in grasses.
    Science 277 : 696-699 (1997). [PMID: 9235894]
  3. Frey, M., Stettner, C., Paré, P.W., Schmelz, E.A., Tumlinson, J.H. and Gierl, A.
    An herbivore elicitor activates the gene for indole emission in maize.
    Proc. Natl. Acad. Sci. USA 97 : 14801-14806 (2000). [PMID: 11106389]
  4. Melanson, D., Chilton, M.-D., Masters-Moore, D. and Chilton, W.S.
    A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize.
    Proc. Natl. Acad. Sci. USA 94 : 13345-13350 (1997). [PMID: 9371848]

[EC created 1961, deleted 1972, reinstated 2006]