EC 4.1.2.50 - 6-carboxytetrahydropterin synthase

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IntEnz Enzyme Nomenclature
EC 4.1.2.50

Names

Accepted name:
6-carboxytetrahydropterin synthase
Other names:
CPH4 synthase
queD (gene name)
Systematic name:
7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming)

Reaction

Cofactor

Comments:

Binds Zn2+. Isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine. The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0070497
UniProtKB/Swiss-Prot: (21) [show] [UniProt]

References

  1. McCarty, R. M., Somogyi, A., Bandarian, V.
    Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase.
    Biochemistry 48: 2301-2303 (2009). [PMID: 19231875]

[EC 4.1.2.50 created 2012]