EC - trans-o-hydroxybenzylidenepyruvate hydratase-aldolase

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IntEnz Enzyme Nomenclature


Accepted name:
trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
Other names:
2'-hydroxybenzalpyruvate aldolase
tHBPA hydratase-aldolase
Systematic name:
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase



This enzyme is involved in naphthalene degradation. The enzyme catalyses a retro-aldol reaction in vitro, and it accepts a broad range of aldehydes and 4-substituted 2-oxobut-3-enoates as substrates [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018813


  1. Kuhm, A. E., Knackmuss, H. J., Stolz, A.
    Purification and properties of 2'-hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates.
    J. Biol. Chem. 268 : 9484-9489 (1993). [PMID: 8486638]
  2. Keck, A., Conradt, D., Mahler, A., Stolz, A., Mattes, R., Klein, J.
    Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6.
    Microbiology 152 : 1929-1940 (2006). [PMID: 16804169]
  3. Eaton, R. W.
    Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid.
    J. Bacteriol. 176 : 7757-7762 (1994). [PMID: 8002605]
  4. Eaton, R. W.
    trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst.
    Appl. Environ. Microbiol. 66 : 2668-2672 (2000). [PMID: 10831455]

[EC created 2010]