EC 4.1.2.44 - 2,3-epoxybenzoyl-CoA dihydrolase

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IntEnz Enzyme Nomenclature
EC 4.1.2.44

Names

Accepted name:
2,3-epoxybenzoyl-CoA dihydrolase
Other names:
BoxC
2,3-dihydro-2,3-dihydroxybenzoyl-CoA lyase/hydrolase (deformylating)
dihydrodiol transforming enzyme
benzoyl-CoA oxidation component C
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA semialdehyde-lyase (formate-forming)
benzoyl-CoA-dihydrodiol lyase [incorrect]
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA-semialdehyde-lyase (formate-forming)
Systematic name:
2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming)

Reaction

Comments:

The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway of the bacterium Azoarcus evansii. The enzyme converts 2,3-epoxy-2,3-dihydrobenzoyl-CoA to its oxepin form prior to the ring-opening and the formation of a dialdehyde intermediate. Formerly EC 4.1.2.n1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Gescher, J., Eisenreich, W., Worth, J., Bacher, A., Fuchs, G.
    Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme.
    Mol. Microbiol. 56 : 1586-1600 (2005). [PMID: 15916608]
  2. Rather, L. J., Knapp, B., Haehnel, W., Fuchs, G.
    Coenzyme A-dependent aerobic metabolism of benzoate via epoxide formation.
    J. Biol. Chem. 285 : 20615-20624 (2010). [PMID: 20452977]

[EC 4.1.2.44 created 2010, modified 2015]