EC - 4-hydroxy-3-polyprenylbenzoate decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxy-3-polyprenylbenzoate decarboxylase
Other names:
ubiD (gene name)
4-hydroxy-3-solanesylbenzoate decarboxylase
3-octaprenyl-4-hydroxybenzoate decarboxylase
Systematic name:
4-hydroxy-3-polyprenylbenzoate carboxy-lyase



The enzyme catalyses a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphate synthase that exists in the specific organism. It requires a prenylated flavin cofactor that is produced by EC, flavin prenyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008694
UniProtKB/Swiss-Prot: (145) [show] [UniProt]


  1. Leppik, R. A., Young, I. G., Gibson, F.
    Membrane-associated reactions in ubiquinone biosynthesis in Escherichia coli. 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase.
    Biochim. Biophys. Acta 436 : 800-810 (1976). [PMID: 782527]
  2. Gulmezian, M., Hyman, K. R., Marbois, B. N., Clarke, C. F., Javor, G. T.
    The role of UbiX in Escherichia coli coenzyme Q biosynthesis.
    Arch. Biochem. Biophys. 467 : 144-153 (2007). [PMID: 17889824]
  3. Pfaff, C., Glindemann, N., Gruber, J., Frentzen, M., Sadre, R.
    Chorismate pyruvate-lyase and 4-hydroxy-3-solanesylbenzoate decarboxylase are required for plastoquinone biosynthesis in the cyanobacterium Synechocystis sp. PCC6803.
    J. Biol. Chem. 289 : 2675-2686 (2014). [PMID: 24337576]
  4. Lin, F., Ferguson, K.L., Boyer, D.R., Lin, X.N. and Marsh, E.N.
    Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase.
    ACS Chem. Biol. (2015). [PMID: 25647642]
  5. Payne, K. A., White, M. D., Fisher, K., Khara, B., Bailey, S. S., Parker, D., Rattray, N. J., Trivedi, D. K., Goodacre, R., Beveridge, R., Barran, P., Rigby, S. E., Scrutton, N. S., Hay, S., Leys, D.
    New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.
    Nature 522 : 497-501 (2015). [PMID: 26083754]

[EC created 2014, modified 2015]