IntEnz

EC 4.1.1.95 - L-glutamyl-[BtrI acyl-carrier protein] decarboxylase

IntEnz Enzyme Nomenclature
EC 4.1.1.95

Names

Reaction

• 53956 [IUBMB]
  γ-L-glutamyl-[BtrI ACP]

  gamma-L-glutamyl-[BtrI ACP]

  GENERIC:13742

  Is ROOT: no
  ROOT compound: GENERIC:13739

  Number of residues: 1

  O-[S-γ-L-glutamylpantetheine-4'-phosphoryl]serine residue O-[S-gamma-L-glutamylpantetheine-4'-phosphoryl]serine residue Name origin: UniProt - CHECKED (C) CHEBI:137996 Formula: C19H32N4O11PS Charge: -1 Position: undefined ChEBI compound status: CHECKED (C)

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  =

  4-aminobutanoyl-[BtrI ACP]

  4-aminobutanoyl-[BtrI ACP]

  GENERIC:13744

  Is ROOT: no
  ROOT compound: GENERIC:13739

  Number of residues: 1

  O-[S-4-aminobutanoylpantetheine-4'-phosphoryl]serine residue O-[S-4-aminobutanoylpantetheine-4'-phosphoryl]serine residue Name origin: UniProt - CHECKED (C) CHEBI:137997 Formula: C18H33N4O9PS Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  CO₂

  CO2

  Name origin: UniProt - CHECKED (C)

  CHEBI:16526

  Formula: CO2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

Cofactor

• pyridoxal 5'-phosphate

Comments:

Binds pyridoxal 5'-phosphate. Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein.

Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein.

Links to other databases

References

1. Li, Y., Llewellyn, N. M., Giri, R., Huang, F., Spencer, J. B.
   Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway.
   Chem. Biol. 12 : 665-675 (2005). [PMID: 15975512]

[EC 4.1.1.95 created 2012]