EC 4.1.1.86 - Diaminobutyrate decarboxylase

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IntEnz Enzyme Nomenclature
EC 4.1.1.86

Names

Accepted name:
diaminobutyrate decarboxylase
Other names:
DABA DC
L-2,4-diaminobutyrate decarboxylase
L-2,4-diaminobutanoate carboxy-lyase
Systematic name:
L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming)

Reaction

Cofactors

Comments:

A pyridoxal-phosphate protein that requires a divalent cation for activity [1]. N4-Acetyl-L-2,4-diaminobutanoate, 2,3-diaminopropanoate, ornithine and lysine are not substrates. Found in the proteobacteria Haemophilus influenzae and Acinetobacter baumannii. In the latter, it is a product of the ddc gene that also encodes EC 2.6.1.76, diaminobutyrat—2-oxoglutarate transaminase, which can supply the substrate for the decarboxylase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033983
UniProtKB/Swiss-Prot:

References

  1. Yamamoto, S., Tsuzaki, Y., Tougou, K. and Shinoda, S.
    Purification and characterization of L-2,4-diaminobutyrate decarboxylase from Acinetobacter calcoaceticus.
    J. Gen. Microbiol. 138: 1461-1465 (1992). [PMID: 1512577]
  2. Ikai, H. and Yamamoto, S.
    Cloning and expression in Escherichia coli of the gene encoding a novel L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii.
    FEMS Microbiol. Lett. 124: 225-228 (1994). [PMID: 7813892]
  3. Ikai, H. and Yamamoto, S.
    Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii.
    J. Bacteriol. 179: 5118-5125 (1997). [PMID: 9260954]

[EC 4.1.1.86 created 2006]