EC - 4-hydroxyphenylacetate decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxyphenylacetate decarboxylase
Other names:
p-hydroxyphenylacetate decarboxylase
4-hydroxyphenylacetate carboxy-lyase
Systematic name:
4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)



The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. The enzyme is a glycyl radical enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043722
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. D'Ari, L., Barker, H. A.
    p-Cresol formation by cell-free extracts of Clostridium difficile.
    Arch. Microbiol. 143 : 311-312 (1985). [PMID: 3938267]
  2. Selmer, T. and Andrei, P.I.
    p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol.
    Eur. J. Biochem. 268 : 1363-1372 (2001). [PMID: 11231288]
  3. Andrei, P.I., Pierik, A.J., Zauner, S., Andrei-Selmer, L.C. and Selmer, T.
    Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity.
    Eur. J. Biochem. 271 : 2225-2230 (2004). [PMID: 15153112]

[EC created 2005]