EC 4.1.1.72 - Branched-chain-2-oxoacid decarboxylase

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IntEnz Enzyme Nomenclature
EC 4.1.1.72

Names

Accepted name:
branched-chain-2-oxoacid decarboxylase
Other names:
BCKA
branched-chain alpha-keto acid decarboxylase
branched-chain keto acid decarboxylase
branched-chain oxo acid decarboxylase
(3S)-3-methyl-2-oxopentanoate carboxy-lyase
Systematic name:
(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)

Reactions

Comments:

Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047433
CAS Registry Number: 63653-19-0
UniProtKB/Swiss-Prot:

References

  1. Oku, H. and Kaneda, T.
    Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase.
    J. Biol. Chem. 263: 18386-18396 (1988). [PMID: 3142877]

[EC 4.1.1.72 created 1990]