EC - 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
Other names:
5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase
5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase
5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)
Systematic name:
(3E,5R)-5-carboxy-2-oxohept-3-enedioate carboxy-lyase [(4Z)-2-oxohept-4-enedioate-forming]



Requires Mg2+ [2,3]. Part of the 4-hydroxyphenylacetate degradation pathway in Escherichia coli C.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018800
CAS Registry Numbers: 148619-60-7 151404-80-7 173015-33-3


  1. Garrido-Pertierra, A. and Cooper, R.A.
    Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
    Eur. J. Biochem. 117 : 581-584 (1981). [PMID: 7026235]
  2. Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P.
    Characterization of a dienol intermediate in the 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase reaction.
    J. Am. Chem. Soc. 114 : 11001-111003 (1992).
  3. Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P.
    Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications.
    J. Am. Chem. Soc. 117 : 8719-8726 (1995).

[EC created 1984]