EC - Indole-3-glycerol-phosphate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
indole-3-glycerol-phosphate synthase
Other names:
indole-3-glycerophosphate synthase
indoleglycerol phosphate synthase
indoleglycerol phosphate synthetase
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)
Systematic name:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(indol-3-yl)glycerol-3-phosphate-forming]



In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC (anthranilate phosphoribosyltransferase), EC (anthranilate synthase), EC (tryptophan synthase) and EC (phosphoribosylanthranilate isomerase)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00536
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004425
CAS Registry Number: 9031-60-1
UniProtKB/Swiss-Prot: (407) [show] [UniProt]


  1. Creighton, T.E. and Yanofsky, C.
    Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon.
    J. Biol. Chem. 241 : 4616-4624 (1966). [PMID: 5332729]
  2. Creighton, T.E. and Yanofsky, C.
    Chorismate to tryptophan (Escherichia coli) - anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase.
    Methods Enzymol. 17A : 365-380 (1970).
  3. Hütter, R., Niederberger, P. and DeMoss, J.A.
    Tryptophan biosynthetic genes in eukaryotic microorganisms.
    Annu. Rev. Microbiol. 40 : 55-77 (1986). [PMID: 16526091]

[EC created 1972]