EC - Uroporphyrinogen decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
uroporphyrinogen decarboxylase
Other names:
porphyrinogen carboxy-lyase
porphyrinogen decarboxylase
uroporphyrinogen III decarboxylase
uroporphyrinogen-III carboxy-lyase
Systematic name:
uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)



Acts on a number of porphyrinogens.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00705
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004853
CAS Registry Number: 9024-70-8
UniProtKB/Swiss-Prot: (515) [show] [UniProt]


  1. Mauzerall, D. and Granick, S.
    Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase.
    J. Biol. Chem. 232 : 1141-1162 (1958). [PMID: 13549492]
  2. Tomio, J.M., Garcia, R.C., San Martin de Viale, L.C. and Grinstein, M.
    Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties.
    Biochim. Biophys. Acta 198 : 353-363 (1970). [PMID: 4984554]

[EC created 1965]