EC - Histidine decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
histidine decarboxylase
Other names:
L-histidine decarboxylase
L-histidine carboxy-lyase
Systematic name:
L-histidine carboxy-lyase (histamine-forming)




A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00329
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004398
CAS Registry Number: 9024-61-7
UniProtKB/Swiss-Prot: (25) [show] [UniProt]


  1. Epps, H.M.R.
    Studies on bacterial amino-acid decarboxylases. 4. l(-)-Histidine decarboxylase from Cl. welchii type A.
    Biochem. J. 39: 42-46 (1945).
  2. Riley, W.O. and Snell, E.E.
    Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group.
    Biochemistry 7: 3520-3528 (1968). [PMID: 5681461]
  3. Rosenthaler, J., Guirard, B.M., Chang, G.W. and Snell, E.E.
    Purification and properties of histidine decarboxylase from Lactobacillus 30a.
    Proc. Natl. Acad. Sci. USA 54: 152-158 (1965). [PMID: 5216347]

[EC created 1961]