EC - Glutamate decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
glutamate decarboxylase
Other names:
γ-glutamate decarboxylase
L-glutamate α-decarboxylase
L-glutamic acid decarboxylase
L-glutamic decarboxylase
aspartate 1-decarboxylase
aspartic α-decarboxylase
cysteic acid decarboxylase
L-glutamate 1-carboxy-lyase
Systematic name:
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)




A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00329
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004351
CAS Registry Number: 9024-58-2
UniProtKB/Swiss-Prot: (45) [show] [UniProt]


  1. Ambe, L. and Sohonie, K.
    Purification and properties of glutamate decarboxylase from the field bean (Dolichos lablab).
    Enzymologia 26 : 98-107 (1963).
  2. Nakano, Y. and Kitaoka, S.
    L-Aspartate α-decarboxylase in a cell-free system from Escherichia coli.
    J. Biochem. (Tokyo) 70 : 327-334 (1971). [PMID: 4937550]
  3. Roberts, E. and Frankel, S.
    Further studies of glutamic acid decarboxylase in brain.
    J. Biol. Chem. 190 : 505-512 (1951). [PMID: 14841200]

[EC created 1961]